Solutions
ADMETRx focuses on redefining drug discovery everyday. Our multi-criteria optimization approaches will apply to all stages of discovery and development, using all information available. With our extensive big Pharma experience and widely acknowledged ADME expertise, we have developed a more effective means of problem-solving in drug discovery.
Our customers deserve more than the traditional “go/no-go” decision-making model that has historically been used to select which drug candidates are advanced through the various discovery and development phases. Instead, we show our customers the potential compensatory trade-offs in a compound’s properties that, when balanced, promote successful lead selection and optimization, and ultimately successful in vivo performance.
This process of knowledge-based guidance can lead to improved effectiveness overall, often demonstrated by expedited timeframes and reduced developmental costs.
To understand how we do this, consider a few of the challenges our customers have faced.
- Prioritizing compounds for in vivo PK studies
- CNS penetration
- Drug-drug interactions
- Interpreting in vivo PK results
- Delivery and formulation challenges
These examples illustrate the versatility of the ADMETRx approach to providing solutions to our client’s discovery challenges. ADMETRx also continually develops new tools to address currently unmet needs and challenges of the future. Contact us to learn more about how the ADMETRx approach can help improve the effectiveness of your discovery programs.
Learn more about ADMETRx services.