How do we prioritize compounds for in vivo PK studies?
Solution: in vitro assessment of absorption potential and oral bioavailability
Oral absorption and bioavailability are dependent on a number of physiological and compound-based properties, many of which can be measured in vitro. Cellular permeability, aqueous and physiologically relevant solubilities and metabolic stability measurements are incorporated in multicriteria decision-making models to rank absorption or bioavailability of compounds before first in animal studies.