What is the likelihood of drug-drug interactions?
Solution: In vitro profiling of transporter & CYP inhibition potential
Drug distribution and clearance are dictated in large part by metabolic pathways and active transport mechanisms in a variety of tissues. Inhibition of these pathways can lead to dramatic changes in concentrations of co-administered drugs. ADMETRx applies a battery of cell-based in vitro transporter and metabolic enzyme inhibition assays to assess potential for such drug-drug interactions.